DTI tractography of lissencephaly caused by TUBA1A mutation
نویسندگان
چکیده
منابع مشابه
Measures for validation of DTI tractography
The evaluation of analysis methods for diffusion tensor imaging (DTI) remains challenging due to the lack of gold standards and validation frameworks. Significant work remains in developing metrics for comparing fiber bundles generated from streamline tractography. We propose a set of volumetric and tract oriented measures for evaluating tract differences. The different methods developed for th...
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Tractography algorithms have been developed to reconstruct likely WM pathways in the brain from diffusion tensor imaging (DTI) data. In this study, an elegant and simple means for improving existing tractography algorithms is proposed by allowing tracts to propagate through diagonal trajectories between voxels, instead of only rectilinearly to their facewise neighbors. A series of tests (using ...
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Lissencephalies are congenital malformations responsible for epilepsy and mental retardation in children. A number of distinct lissencephaly syndromes have been characterized, according to the aspect and the topography of the cortical malformation, the involvement of other cerebral structures and the identified genetic defect. A mutation in TUBA1A, coding for alpha 1 tubulin, was recently ident...
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INTRODUCTION The diffusion tensor is always measured in the presence of background noise. Within the framework of recently proposed methods of error propagation and of 1-order matrix perturbation for DTI [1,2], one can easily characterize the noise induced variability of the estimated tensor itself and of tensorderived quantities, scalar or vector. Of particular interest in tractography is the ...
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Lissencephaly is a cortical malformation secondary to impaired neuronal migration resulting in mental retardation, epilepsy and motor impairment. It shows a severity spectrum from agyria with a severely thickened cortex to posterior band heterotopia only. The LIS1 gene on 17p13.3 encodes a 45 kDa protein named PAFAH1B1 containing seven WD40 repeats. This protein is required for optimal neuronal...
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ژورنال
عنوان ژورنال: Neurological Sciences
سال: 2014
ISSN: 1590-1874,1590-3478
DOI: 10.1007/s10072-014-1662-3