Drugs acting on central nervous system (CNS) targets as leads for non-CNS targets

Drugs acting on central nervous system (CNS) targets as leads for non-CNS targets

Out-of-the-box approaches are currently needed to replenish the souring pipelines of pharmaceutical companies across the globe. Here a theme is presented - the use of central nervous system (CNS) drugs as leads for non-CNS targets. The approach is related to the use of existing drugs for new indications. Suitable chemical modifications of the CNS drugs abolish their CNS penetration. These novel...

P134: Central Nervous System and Blood Biomarker in Stroke, CNS Bleeding, Epilepsy, and Traumatic CNS Injury; MicroRNAs

A Central nervous system (CNS) hemorrhage is bleeding in or around the brain and spinal cord. Reasons of CNS hemorrhage include high blood pressure, cancers, drug abuse, abnormally weak blood vessels that leakage, and trauma. Regression of CNS bleeding was confirmed to be relatively repetitive in patients with severe FV, FX, FVII and FXIII deficiencies. Generally in CNS hemorrhage, radiological...

Passive permeability and P-glycoprotein-mediated efflux differentiate central nervous system (CNS) and non-CNS marketed drugs.

Membrane permeability and P-glycoprotein (Pgp) can be limiting factors for blood-brain barrier penetration. The objectives of this study were to determine whether there are differences in the in vitro permeability, Pgp substrate profiles, and physicochemical properties of drugs for central nervous system (CNS) and non-CNS indications, and whether these differences are useful criteria in selecti...

[Drugs acting on the central nervous system].

Challenging New Targets for CNS–HIV Infection

THE CENTRAL NERVOUS SYSTEM (CNS) REPRESENTS AN IMPORTANT TARGET FOR HIV INFECTION DURING MULTIPLE STAGES OF THE DISEASE: early, after invasion of the host, acting as a viral reservoir; lately, subverting its function and causing peripheral neuropathies and neurocognitive disorders; and lastly, during the final stage of NeuroAIDS, triggering opportunistic infections, cancers, and dementia. Highl...