Drug repurposing: Ibrutinib exhibits immunosuppressive potential in organ transplantation
نویسندگان
چکیده
منابع مشابه
State of immunosuppressive agents in organ transplantation.
TRANSPLANT A nON has been built on the foundation of using drug thera.py to nonspecifically suppress the recipient immune response. Failure to achieve adequate immunosuppression is associated with a high incidence of graft loss from rejection. The present goal of immunosuppressive regimens is to suppress the immune response to the allograft while preserving sufficient immunity to avoid opportun...
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ABSTRACT Immunosuppressive agents have revolutionized clinical transplantation medicine, allowing the avoidance of immune system attack on the transplanted graft. Nevertheless, the use of medications such as cyclosporine, tacrolimus and others also brought the side effects of these drugs. Early identification of drug-induced neurotoxicity in transplanted patients and of its specific causes is i...
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In recent years solid organ transplantation has been rapidly developed as a therapeutic intervention that is life-saving and greatly contributes to a better quality of life in organ recipients. The rapid development has been made possible because of a drastic expansion in the immunosuppressive repertoire. Unfortunately, the side effects of these drugs can be severe, which is one of the reasons ...
متن کاملImmunosuppressive Strategies in Solid Organ Transplantation 141 IMMUNOSUPPRESSIVE STRATEGIES IN SOLID ORGAN TRANSPLANTATION Pharmacotherapy Self-Assessment Program, 5th Edition
1. Justify the rationale for using multiple drug regimens in recipients of solid organ transplants. 2. Analyze the limitations of established immunosuppressive strategies. 3. Evaluate the relative benefits and risks of withdrawal and avoidance immunosuppressive strategies. 4. Design and implement immunosuppressive strategies aimed at decreasing toxicity and improving long-term patient outcomes....
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Exploiting the inherent promiscuity of drugs can enable recognition of important " off-target " effects that can be leveraged to repurpose drugs toward medical conditions not originally intended. Perhaps the classic example is the repurposing of imatinib, originally intended for breakpoint cluster region-Abelson murine leukemia viral onco-gene homolog 1 (BCR-ABL)-driven chronic myelogenous leuk...
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ژورنال
عنوان ژورنال: International Journal of Medical Sciences
سال: 2018
ISSN: 1449-1907
DOI: 10.7150/ijms.24460