Drug points: Mefenamic acid nephropathy--acute renal failure in overdose

Irreversible renal failure following mefenamic acid.

Renal failure due to acute phosphate nephropathy.

Case report of a 62-year-old woman who developed acute renal failure due to nephrocalcinosis, also called acute phosphate nephropathy, after large bowel cleansing in preparation for colonoscopy using oral sodium phosphate solution (Phosphoral, de Witt, Cheshire, UK). Subsequently her renal insufficiency resolved only partially resulting in stage 4 chronic kidney disease. In retrospect multiple ...

Acute renal failure associated with a labetalol overdose.

A case of acute renal failure in association with a deliberate labetalol overdose is described. The possible pathogenetic mechanisms behind the deterioration in renal function are discussed. Treatment of beta-blockade overdose, with special emphasis on the place of glucagon in such poisoning, is reviewed.

Quinapril Overdose-Induced Renal Failure

Background: Angiotensin converting enzyme (ACE) inhibitor toxicity is infrequently reported and seldom produces significant clinical effects. Only 15 previous cases of intentional ACE inhibitor overdoses among adults have been published. The most commonly observed clinical effect is hypotension, which is typically transitory and responsive to supportive measures and intravenous hydration. An ad...

Renal Disease—Case-Based Approach to Acute Renal Failure, Chronic Renal Failure and Protein-Losing Nephropathy

The most consistent presenting complaint for patients with chronic renal failure (CRF) and protein-losing nephropathy (PLN) is polyuria/polydipsia (PU/PD), though occasionally the owner does not recognize these clinical signs. Other historical findings for chronic renal failure may include weight loss and decreased appetite. Intermittent vomiting may be seen if secondary uremic gastric ulcers a...