منابع مشابه
Drug metabolism in liver disease.
The liver is the most important site of drug metabolism and patients with liver disease might be expected to have a reduced capacity to metabolize drugs. The rates of elimination of extensively metabolized drugs such as the barbiturates, diazepam, tolbutamide, isoniazid, phenylbutazone, rifampicin, lignocaine, paracetamol, aminopyrine, antipyrine and pethidine have been measured in patients wit...
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Background: The aim of the present study was to investigate the effect of Paprika on the metabolism of lipid changes and hepatic enzyme activities following oxytetracycline administration in rats. Materials and Methods: A total of 36 adult male rats were divided into 6 equal groups and treated as follows. The control group (normal saline), fatty liver FL (oxytetracycline (Erfan drug Company) ...
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L IVER TRANSPLANTATION is a therapeutic option for a number of liver diseases. I While the kinetics of several drugs are known to be altered in liver disease, very little is known about drug kinetics in liver transplant patients. Since liver transplant patients receive multiple drugs, a thorough understanding of the kinetics of these agents is essential for optimization of drug therapy in this ...
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Imatinib is an orally administered tyrosine kinase inhibitor which inhibits the Bcr-Abl protein-tyrosine kinase with high selectivity. Imatinib is rapidly absorbed from the gut, after oral intake and has an almost absolute bioavailability of 98%. The metabolism of imatinib is mediated by the cytochrome P450 (CYP) isoenzymes in the liver and gut wall. CGP74588 is a major active metabolite of ima...
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Oxidative drug metabolism in liver microsomes from uremic rats. Uremia was achieved by subtotal nephrectomy in 50 to 70 day old male rats weighing 252.0± 20.1 g. Nephrectomized rats and sham-operated controls were sacrificed six days later. After liver microsomes had been isolated, microsomal cytochrome P-450 and cytochrome b5 content as well as microsomal specific activity for N-demethylation ...
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ژورنال
عنوان ژورنال: Japanese Journal of Pharmacology
سال: 1977
ISSN: 0021-5198
DOI: 10.1016/s0021-5198(19)60574-3