DRUG METABOLISM

Principles of Drug Metabolism

Xenobiotic metabolism, which includes drug metabolism, has become a major pharmacological science with particular relevance to biology, therapeutics and toxicology. Drug metabolism is also of great importance inmedicinal chemistry because it influences in qualitative, quantitative, and kinetic terms the deactivation, activation, detoxification, and toxification of the vast majority of drugs. As...

Phase II Drug Metabolism

Genetics in Drug Metabolism

Genomic variation largely explains the differences in an individual’s response to drug treatments. A field of genomic medicine focuses on the identification of genetic polymorphisms and gene mutations involved in the development and progression of disease. Another part focuses on the development of genetic tests to accompany medical prescriptions, to predict how certain patients respond to ther...

Renal drug metabolism.

Drug metabolism and hepatotoxicity.

Drug metabolism in the 1960s At the time the Liver Unit was established in 1966, interest in the study of drug metabolism was growing, stimulated largely by the pharmaceutical industry, and the legislative requirements imposed upon it. It represented a remarkable change from the situation a few years previously when'. . . the study ofthe metabolism of foreign compounds was not a popular one; bi...