Drug combination and repurposing for cancer therapy: the example of breast cancer

Drug Repurposing for Cancer Therapy.

In the mid-1980s, a French company geared its efforts toward developing a synthetic steroid capable of blocking the glucocorticoid receptor in order to potentially treat Cushing’s syndrome. Preclinical studies revealed that the compound developed, termed RU-38486, was indeed a potent antiglucocorticoid agent [1], yet with a caveat: if given to pregnant animals, it terminated pregnancy [2-4]. Th...

Repurposing of drug candidates for treatment of skin cancer

Skin cancers are highly prevalent malignancies that affect millions of people worldwide. These include melanomas and nonmelanoma skin cancers. Melanomas are among the most dangerous cancers, while nonmelanoma skin cancers generally exhibit a more benign clinical pattern; however, they may sometimes be aggressive and metastatic. Melanomas typically appear in body regions exposed to the sun, alt...

the study of aaag repeat polymorphism in promoter of errg gene and its association with the risk of breast cancer in isfahan region

چکیده: سرطان پستان دومین عامل مرگ مرتبط با سرطان در خانم ها است. از آنجا که سرطان پستان یک تومور وابسته به هورمون است، می تواند توسط وضعیت هورمون های استروئیدی شامل استروژن و پروژسترون تنظیم شود. استروژن نقش مهمی در توسعه و پیشرفت سرطان پستان ایفا می کند و تاثیر خود را روی بیان ژن های هدف از طریق گیرنده های استروژن اعمال می کند. اما گروه دیگری از گیرنده های هسته ای به نام گیرنده های مرتبط به ا...

Repurposing ARBs as treatments for breast cancer

Metacognitive Therapy and Depression of Women with Breast Cancer

Objective: This study aimed to examine the effectiveness of metacognitive therapy on decreasing depression in women with breast cancer. A single-case design was employed in this research.  Methods: An AB form of single-subject experimental design was used in this study with 3 baselines (every 10 days) before intervention stage and two measurements during intervention stage and one follow-up ...