Dramatic Aggravation of Partial Seizures Induced by Gabapentin Overdose
نویسندگان
چکیده
منابع مشابه
Gabapentin Abuse and Overdose: A Case Report
The abuse potential of drugs that stimulate dopamine release has driven the search for drugs that influence alternate neurotransmitters, and the glutaminergic pathway is a potential target for the development of new therapeutic practices [1]. Gabapentin is one such drug that modulates GABA and glutamate levels; its clinical effectiveness has been reported across a wide variety of disorders rang...
متن کاملSimple partial seizures aggravated or induced by benzodiazepine injection
Seizure aggravation by antiepileptic drugs (AEDs) is increasingly recognized as a common problem, particularly in idiopathic generalized epilepsy (IGE). Benzodiazepines (BZDs) are one type of the main AEDs, especially in the treatment of status epilepticus. Paradoxical worsening of seizures associated with BZD is uncommon and most reports are among pediatric patients [1–3]. We report the case o...
متن کاملCosts, work absence, and adherence in patients with partial onset seizures prescribed gabapentin or pregabalin.
BACKGROUND/OBJECTIVE Few studies have examined cost of illness of epileptic partial onset seizures (POS) from the employer perspective or compared users of gabapentin and pregabalin in treatment of POS. This study compares pharmacotherapy, direct/indirect costs, and work absences of patients with POS newly started on gabapentin or pregabalin. METHODS Data from employees and dependent spouses ...
متن کاملAdjunctive pregabalin vs gabapentin for focal seizures
OBJECTIVE To evaluate the comparative safety and adjunctive efficacy of pregabalin and gabapentin in reducing seizure frequency in patients with partial-onset seizures based on prestudy modeling showing superior efficacy for pregabalin. METHODS The design of this comparative efficacy and safety study of pregabalin and gabapentin as adjunctive treatment in adults with refractory partial-onset ...
متن کاملThe mechanism of carbamazepine aggravation of absence seizures.
Carbamazepine (CBZ) aggravates many generalized seizures types, particularly absence seizures, but the mechanisms underlying this are poorly understood. GABA signaling within the reticular nucleus (Rt) and the ventrobasal complex (VB) of the thalamus is critical to the neurophysiology of absence seizures. The hypothesis that CBZ aggravates absence seizures by acting at the VB thalamus via a GAB...
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ژورنال
عنوان ژورنال: Epilepsy & Seizure
سال: 2008
ISSN: 1882-5567
DOI: 10.3805/eands.1.40