منابع مشابه
Chromatin Unfolds
sites near the ends are most accessible, but even sites near the center of the nucleosome can be attacked, National Institute of Diabetes and Digestive and Kidney Diseases though less readily. The results are consistent with a free energy of binding of DNA to the nucleosome surface National Institutes of Health Bethesda, Maryland 20892-0540 of 0.1–0.15 kcal/mol bp in the range of ionic strength...
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متن کاملSugarcoating ER Stress
The hexosamine biosynthetic pathway (HBP) generates metabolites for protein N- and O-glycosylation. Wang et al. and Denzel et al. report a hitherto unknown link between the HBP and stress in the endoplasmic reticulum. These studies establish the HBP as a critical component of the cellular machinery of protein homeostasis.
متن کاملEndoplasmic reticulum (ER) stress & diabetes.
The endoplasmic reticulum (ER) is a central organelle entrusted with lipid synthesis, protein folding and protein maturation. It is endowed with a quality control system that facilitates the recognition and targeting of aberrant proteins for degradation. When the capacity of this quality control system is exceeded, a stress response (ER stress) is switched on. Prolonged stress leads to apoptosi...
متن کاملThe Story Unfolds
The middle of 2007 saw what may, with time, turn out to be the single most important discovery in the genetics of cardiovascular diseases. Within a few weeks, 4 independent genomewide association studies reported the association of the same locus on chromosome 9p21 with coronary artery disease (CAD) and myocardial infarction (MI).1– 4 In fact, of the hundreds of thousands single-nucleotide poly...
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ژورنال
عنوان ژورنال: Nature Reviews Molecular Cell Biology
سال: 2014
ISSN: 1471-0072,1471-0080
DOI: 10.1038/nrm3843