Dr James Riley, pioneer in histamine and mast cell studies

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Temperature Dependence of Mast Cell Histamine Secretion

A diverse set of direct experimental observations and theoretical considerations supports the existence of fluidity in cell membranes (1) . Several membrane-dependent functions of Escherichia coli have been shown to exhibit biphasic Arrhenius plots with transition temperatures that are determined by the degree and configuration of the unsaturation of fatty acids incorporated into the membrane p...

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Mast Cell-Derived Histamine Mediates Cystitis Pain

BACKGROUND Mast cells trigger inflammation that is associated with local pain, but the mechanisms mediating pain are unclear. Interstitial cystitis (IC) is a bladder disease that causes debilitating pelvic pain of unknown origin and without consistent inflammation, but IC symptoms correlate with elevated bladder lamina propria mast cell counts. We hypothesized that mast cells mediate pelvic pai...

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Dr James Macrae

Ham Green Hospital, Bristol from 1948 to 1976 died on 5th February 1987 aged 75 years. He was born on 24th February 1911 at Kyle of Locha'5. and educated at Dingwall Academy and Glasgow versity where he qualified in 1934. During the following years he held junior hospital posts in virtually everV medical and surgical speciality and in 1939 appointed Deputy Medical Superintendant of Lana^ shire ...

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Mast cell and histamine involvement in farmer's lung disease.

The aim of this study was to evaluate the cellular and biochemical characteristics of the bronchoalveolar lavage (BAL) fluid in patients with farmer's lung disease (FLD). Total cell numbers in BAL fluids from patients with FLD (n = 30) were significantly higher than in normal subjects (n = 7; p < 0.01), and differential cell counts were significantly different. Lymphocytes were the most numerou...

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Local mast cell histamine and plasma histamine levels in neurofibromatosis type 1.

Cutaneous neurofibroma 1/9/M 0 1.15 ND + + 2/10/M 0 0.62 ND 3/10/F 0 0.99 ND 4/14/M 1–10 1.32 ND 5/24/F 1–10 1.31 ND + + 6/27/M 11–100 0.65 15.6 (T) + + 7/32/M 11–100 0.52 ND 8/35/M 11–100 0.55 ND 9/36/M 101–1000 0.17 85.2 (T) 10/37/F 11–100 0.51 20.4 (H) 11/38/F 101–1000 0.52 ND 12/51/F 101–1000 0.29 10 (E) 13/59/F 11–100 0.41 ND 14/62/F 11–100 0.56 ND 15/63/F 11–100 0.38 ND + 16/66/F 101–1000...

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ژورنال

عنوان ژورنال: Journal of the Royal College of Physicians of Edinburgh

سال: 2019

ISSN: 1478-2715,2042-8189

DOI: 10.4997/jrcpe.2019.316