Downregulation of MEIS1 impairs long-term expansion of CD34+ NPM1-mutated acute myeloid leukemia cells
نویسندگان
چکیده
منابع مشابه
Clonal evolution in relapsed NPM1-mutated acute myeloid leukemia.
Mutations in the nucleophosmin 1 (NPM1) gene are considered a founder event in the pathogenesis of acute myeloid leukemia (AML). To address the role of clonal evolution in relapsed NPM1-mutated (NPM1mut) AML, we applied high-resolution, genome-wide, single-nucleotide polymorphism array profiling to detect copy number alterations (CNAs) and uniparental disomies (UPDs) and performed comprehensive...
متن کاملMutated NPM1 in combination with overexpression of Meis1 or Hoxa9 is not sufficient to induce acute myeloid leukemia
BACKGROUND Acute myeloid leukemia (AML) carrying nucleophosmin 1 (NPM1) mutations (NPMc(+)) is regarded as a separate entity of myeloid neoplasms due to its distinct biological and clinical features. However, NPMc(+) alone displays low leukemogenic activity and cooperating events appear crucial for AML to develop. Dysregulation of homeobox genes, such as HOXA9 and MEIS1, is a common transcripti...
متن کاملMYELOID NEOPLASIA Leukemia-initiating cells from some acute myeloid leukemia patients with mutated nucleophosmin reside in the CD34 fraction
Leukemia-initiating cells (LICs) in acute myeloid leukemia (AML) are believed to be restricted to the CD34 fraction. However, one of the most frequently mutated genes in AML is nucleophosmin (NPM), and this is associated with low CD34 expression. We, therefore, investigated whether NPM-mutated AMLs have LICs restricted to the CD34 fraction. We transplanted sorted fractions of primary NPMmutated...
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G, Wassmann B, et al. Sustained complete molecular remissions after treatment with imatinib-mesylate in patients with failure after allogeneic stem cell transplantation for chronic myelogenous leukemia: results of a prospective phase II open-label multicenter study. J Clin Oncol 2005;23:7583-93. 8. Dazzi F, Szydlo RM, Craddock C, Cross NC, Kaeda J, Chase A, et al. Comparison of single-dose and ...
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within the PhD Program of the Center for Molecular Medicine in Vienna, Austria. Dr. Robert Kralovics is an independent Principal Investigator at the Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria. The work was supported by grants from the Austrian Science Fund (FWF) and the MPD Foundation. No potential conflicts of interests relevant to this article were repo...
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ژورنال
عنوان ژورنال: Leukemia
سال: 2011
ISSN: 0887-6924,1476-5551
DOI: 10.1038/leu.2011.277