Downregulation of HSPA2 inhibits proliferation via ERK1/2 pathway and endoplasmic reticular stress in lung adenocarcinoma
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چکیده
منابع مشابه
Bostrycin inhibits proliferation of human lung carcinoma A549 cells via downregulation of the PI3K/Akt pathway
BACKGROUND Bostrycin is a novel compound isolated from marine fungi that inhibits proliferation of many cancer cells. However, the inhibitory effect of bostrycin on lung cancers has not been reported. This study is to investigate the inhibitory effects and mechanism of bostrycin on human lung cancer cells in vitro. METHODS We used MTT assay, flow cytometry, microarray, real time PCR, and West...
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Objective: We aimed to investigate the biological role of eukaryotic translation initiation factor 3B (EIF3B) and its mechanism in lung adenocarcinoma (LAD) occurrence. Methods: EIF3B was firstly determined in LAD tissues and cell lines using Western blot and quantitative real-time PCR. EIF3B was then knocked down using RNA interference technology in LAD cell lines, A549 and 95D. Furthermore, f...
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Background: Kinesin spindle protein (KSP) plays a critical role in mitosis. Inhibition of KSP function leads to cell cycle arrest at mitosis and ultimately to cell death. The aim of this study was to suppress KSP expression by specific small-interfering RNA (siRNA) in Hep3B cells and evaluate its anti-tumor activity. Methods: Three siRNA targeting KSP (KSP-siRNA #1-3) and one mismatched-siRNA (...
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Homocysteine is an independent risk factor for coronary, cerebral, and peripheral vascular diseases. Recent studies have shown that levels of homocysteine are elevated in patients with impaired hepatic function, but the precise role of homocysteine in the development of hepatic dysfunction is unclear. In this study, we examined the effect of homocysteine on hepatocyte proliferation in vitro. Ou...
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ژورنال
عنوان ژورنال: Annals of Translational Medicine
سال: 2019
ISSN: 2305-5839,2305-5847
DOI: 10.21037/atm.2019.10.16