Downregulation of alpha7 nicotinic acetylcholine receptor in two-kidney one-clip hypertensive rats
نویسندگان
چکیده
منابع مشابه
Downregulation of alpha7 nicotinic acetylcholine receptor in two-kidney one-clip hypertensive rats
BACKGROUND Inflammation processes are important participants in the pathophysiology of hypertension and cardiovascular diseases. The role of the alpha7 nicotinic acetylcholine receptor (α7nAChR) in inflammation has recently been identified. Our previous study has demonstrated that the α7nAChR-mediated cholinergic anti-inflammatory pathway is impaired systemically in the genetic model of hyperte...
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In normotensive rats, stimulation of renal mechanoreceptors by an increase in ureteral pressure results in a contralateral inhibitory renorenal reflex response with contralateral natriuresis. Similar effects are produced by stimulation of renal chemoreceptors by renal pelvic perfusion with 0.9 M NaCl. However, in spontaneously hypertensive rats the renorenal reflex responses to renal mechanorec...
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ژورنال
عنوان ژورنال: BMC Cardiovascular Disorders
سال: 2012
ISSN: 1471-2261
DOI: 10.1186/1471-2261-12-38