Down-regulated MicroRNAs in Gastric Carcinoma May Be Targets for Therapeutic Intervention and Replacement Therapy

Gastric cancer is one of the leading types with an annual death toll 700,000 worldwide. Despite fact that several agents are approved for its treatment, high percentage recurrence and intractability metastatic disease remain a major problem. The identification new targets modalities treatment therefore priority. We have searched literature microRNAs down-regulated in gastric efficacy cancer-related murine xenograft models after reconstitution therapy. Among identified miRs were 25 targeting transcription factors, seven them regulating cell-cycle apotosis-related targets, five GTPase-related such as GAPs GEFs. According to criteria prognostic impact, functional data, tractability, miR-133 b/a (MCL1) miR-518 (MDM2) suggested potentially valuable further evaluation possible cancer.