Double-strand break repair by interchromosomal recombination: suppression of chromosomal translocations
نویسندگان
چکیده
منابع مشابه
Double-strand break repair by interchromosomal recombination: suppression of chromosomal translocations.
To directly determine whether recombinational repair of double-strand breaks (DSBs) can occur between heterologous chromosomes and lead to chromosomal rearrangements in mammalian cells, we employed an ES cell system to analyze recombination between repeats on heterologous chromosomes. We found that recombination is induced at least 1000-fold following the introduction of a DSB in one repeat. Mo...
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ژورنال
عنوان ژورنال: Genes & Development
سال: 1998
ISSN: 0890-9369
DOI: 10.1101/gad.12.24.3831