Double Duty: Mitotic Kinesins and Their Post-Mitotic Functions in Neurons
نویسندگان
چکیده
منابع مشابه
Inhibitors of Mitotic Kinesins for Cancer Treatment: Consequences for Neurons
Cancer is among the greatest and most expensive medical challenges in the world, and potentially escalating in prevalence as more carcinogens are introduced into the environment. Not surprisingly, there are ongoing efforts to develop novel therapies, as effective treatments would positively impact the landscape for society. Cancer involves abnormal cells that rapidly proliferate, move, and inva...
متن کاملEndogenous localizome identifies 43 mitotic kinesins in a plant cell.
Kinesins are microtubule (MT)-based motor proteins that have been identified in every eukaryotic species. Intriguingly, land plants have more than 60 kinesins in their genomes, many more than that in yeasts or animals. However, many of these have not yet been characterized, and their cellular functions are unknown. Here, by using endogenous tagging, we comprehensively determined the localizatio...
متن کاملCRISPR/Cas9-Mediated Gene Knock-Down in Post-Mitotic Neurons
The prokaryotic adaptive immune system CRISPR/Cas9 has recently been adapted for genome editing in eukaryotic cells. This technique allows for sequence-specific induction of double-strand breaks in genomic DNA of individual cells, effectively resulting in knock-out of targeted genes. It thus promises to be an ideal candidate for application in neuroscience where constitutive genetic modificatio...
متن کاملMitotic Kinesins: A Reason to Delve into Kinesin-12
The failure of kinesin-targeting cancer drugs is thought to result from functional redundancy of mitotic kinesins. A new study provides mechanistic insights into kinesin-12 that help to explain its targeting to kinetochore fibers and its ability to compensate for inhibition of kinesin-5.
متن کاملCooperation between Mitotic Kinesins Controls the Late Stages of Cytokinesis
Cell division is regulated by protein kinases of the Cdk, Polo, and Aurora families. Although it has long been established that temporal control is central to the coordinated action of these kinases, the importance of spatial regulation has only recently been appreciated and is still poorly understood. The kinesin-6 family motor protein MKlp1 is a key regulator of cytokinesis and an ideal subst...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Cells
سال: 2021
ISSN: 2073-4409
DOI: 10.3390/cells10010136