Double Cord Blood Transplantation: Pre-Engraftment or Recessive Cord Rejection Syndrome?
نویسندگان
چکیده
منابع مشابه
Double cord blood transplantation: co-operation or competition?
Over the last two decades umbilical cord blood (UCB) transplantation (UCBT) is increasingly used for a variety of malignant and benign hematological and other diseases. The main factor that limits the use of UCB to low weight recipients, mainly children and adolescents, is its low progenitor cell content. Various alternatives have been exploited to overcome this difficulty, including the transp...
متن کاملImproving Engraftment and Immune Reconstitution in Umbilical Cord Blood Transplantation
Umbilical cord blood (UCB) is an important source of hematopoietic stem cells (HSC) for allogeneic transplantation when HLA-matched sibling and unrelated donors (MUD) are unavailable. Although the overall survival results for UCB transplantation are comparable to the results with MUD, UCB transplants are associated with slow engraftment, delayed immune reconstitution, and increased opportunisti...
متن کاملCurrent Strategies to Improve Engraftment in Cord Blood Transplantation
Umbilical cord blood (UCB) remains an important alternative source of hematopoietic stem cells (HSC) for allogeneic transplantation when suitable HLA-matched donors are unavailable. Cord blood (CB) offers many benefits including rapid availability, absence of risk to the donor, and a low incidence of graft-versus-host disease. However, although the overall survival of patients receiving unrelat...
متن کاملCord colitis syndrome in cord-blood stem-cell transplantation.
BACKGROUND Diarrhea is a frequent complication of hematopoietic stem-cell transplantation (HSCT). Important causes of diarrhea after HSCT include acute graft-versus-host disease (GVHD), infections, and medications. After the transplantation and engraftment of hematopoietic stem cells from umbilical-cord blood, we observed a new syndrome of culture-negative, antibiotic-responsive diarrhea not at...
متن کاملAn in vivo model of double-unit cord blood transplantation that correlates with clinical engraftment.
Double-unit cord blood transplantation (DCBT) appears to enhance engraftment despite sustained hematopoiesis usually being derived from a single unit. To investigate DCBT biology, in vitro and murine models were established using cells from 39 patient grafts. Mononuclear cells (MNCs) and CD34(+) cells from each unit alone and in DCB combination were assessed for colony-forming cell and cobblest...
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ژورنال
عنوان ژورنال: Biology of Blood and Marrow Transplantation
سال: 2012
ISSN: 1083-8791
DOI: 10.1016/j.bbmt.2011.12.198