Dosimetric Support of Radionuclide Therapy
نویسندگان
چکیده
Purpose: Analysis of modern approaches to dosimetric support radionuclide therapy at the technological stages planning, hospitalization in a hospital and evaluation treatment eծectiveness. Material methods: A comparative analysis methodological specifics with introduction radiopharmaceuticals into body conventional radiation using sealed sources ionizing was carried out. Two methodically different planning level internal exposure from radiopharmaceutical introduced patient’s are considered. The features monitoring discussed both for stay department safe discharge others, solid liquid radioactive waste being removed. functionality various criteria assessing long-term short-term effectiveness bone metastases Focal absorbed doses considered as one criteria, determination which simplified method their calculation is proposed based on quantitative data SPECT/CT scanning an X-ray phantom real patient who has been injected β-γ-emitting therapeutic radiopharmaceutical. Results: On clinical example 177 Lu-PSMA-617 stage 4 prostate cancer, dose estimates irradiation foci β-particles were obtained. Calculations made 7 localizations dynamics each 5 fractions course therapy. It shown that total focal vary 70.6 116.8 Gy foci, corresponds literature obtained by more accurate methods dosimetry exposure. compared efficacy metabolic, hematological, hormonal biochemical parameters, well tumor marker PSA. Conclusion: In contrast therapy, evaluating not yet become fundamental basis
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ژورنال
عنوان ژورنال: Onkologi?eskij žurnal: lu?evaâ diagnostika, lu?evaâ terapiâ
سال: 2023
ISSN: ['2587-7593', '2713-167X']
DOI: https://doi.org/10.37174/2587-7593-2023-6-2-66-84