Dose Response Relationship in a Monocrotaline Rat Model of Pulmonary Hypertension

Reversibility of the monocrotaline pulmonary hypertension rat model.

and Marja-Liisa Lokki Transplantation Laboratory, Haartman Institute, University of Helsinki, Helsinki, Raasepori Health Care Centre, Raasepori, FIMM, Institute for Molecular Medicine Finland, Biomedicum, University of Helsinki, Helsinki, and Immunodeficiency Unit, Division of Infectious Diseases, Dept of Medicine, Helsinki University Central Hospital, Helsinki, Finland. Semeco AB, Vejbystrand,...

Protective effects of hydrogen-rich saline on monocrotaline-induced pulmonary hypertension in a rat model

BACKGROUND Hydrogen-rich saline has been reported to have antioxidant and anti-inflammatory effects and effectively protect against organ damage. Oxidative stress and inflammation contribute to the pathogenesis and/or development of pulmonary hypertension. In this study, we investigated the effects of hydrogen-rich saline on the prevention of pulmonary hypertension induced by monocrotaline in a...

MCAF/MCP-1 protein expression in a rat model for pulmonary hypertension induced by monocrotaline.

Exhaled nitric oxide measurement to monitor pulmonary hypertension in a pneumonectomy-monocrotaline rat model.

The use of fractional exhaled nitric oxide (FeNO) has been suggested as a quantitative marker for pulmonary arterial hypertension (PAH) in humans. To further characterize FeNO in PAH we investigated this marker in a rodent model. Since there is no standardized technique for FeNO measurement in animals, we intended to reduce measuring errors and confounders of an existing published method by mat...

The monocrotaline model of pulmonary hypertension in perspective.

Severe forms of pulmonary arterial hypertension (PAH) are characterized by various degrees of remodeling of the pulmonary arterial vessels, which increases the pulmonary vascular resistance and right ventricular afterload, thus contributing to the development of right ventricle dysfunction and failure. Recent years have seen advances in the understanding of the pathobiology of PAH; however, man...