Dose-response relationship and low dose extrapolatioin in chemical carcinogenesis
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چکیده
منابع مشابه
Dose-response relationship in multistage carcinogenesis: promoters.
Published dose-response curves of promoters of multistage carcinogenesis were selected that met the combined criteria of long study times, multiple doses, and low doses. In rat liver, 12 dose-response studies of 7 different promoters (phenobarbital, 2,3,7,8-tetrachlorodibenzo-p-dioxin [TCDD], clophen A-50 (a polychlorinated biphenyl), alpha-, beta-, and gamma-hexachlorocyclohexane [HCH], and ch...
متن کاملLow-dose radiation exposure and carcinogenesis.
Absorption of energy from ionizing radiation by the genetic material in the cell leads to damage to DNA, which in turn leads to cell death, chromosome aberrations and gene mutations. While early or deterministic effects result from organ and tissue damage caused by cell killing, latter two are considered to be involved in the initial events that lead to the development of cancer. Epidemiologica...
متن کاملCarcinogenesis Induced by Low-dose Radiation
Background Although the effects of high dose radiation on human cells and tissues are relatively well defined, there is no consensus regarding the effects of low and very low radiation doses on the organism. Ionizing radiation has been shown to induce gene mutations and chromosome aberrations which are known to be involved in the process of carcinogenesis. The induction of secondary cancers is ...
متن کاملDose-response relationship for breast cancer induction at radiotherapy dose
PURPOSE Cancer induction after radiation therapy is known as a severe side effect. It is therefore of interest to predict the probability of second cancer appearance for the patient to be treated including breast cancer. MATERIALS AND METHODS In this work a dose-response relationship for breast cancer is derived based on(i) the analysis of breast cancer induction after Hodgkin's disease,(ii) ...
متن کاملToxin Response LOW Intermediate High At Least One Dose Dose Dose Dose Placebo
Twenty patients with torticollis had electromyographic studies of their neck muscles performed before and after a series of local injections of botulinum toxin. The pattern of muscle activity changed after the injections, and this effect persisted even after head position had returned to baseline. Patients who did not experience any clinical benefit from the injections also demonstrated a chang...
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ژورنال
عنوان ژورنال: Carcinogenesis
سال: 1990
ISSN: 0143-3334,1460-2180
DOI: 10.1093/carcin/11.8.1243