Dose-Response Curves in Chemical Carcinogenesis
نویسندگان
چکیده
منابع مشابه
Implicit dose-response curves.
We develop tools from computational algebraic geometry for the study of steady state features of autonomous polynomial dynamical systems via elimination of variables. In particular, we obtain nontrivial bounds for the steady state concentration of a given species in biochemical reaction networks with mass-action kinetics. This species is understood as the output of the network and we thus bound...
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A possible experimental design for combination experiments is to compare the dose-response curve of a single agent with the corresponding curve of the same agent using either a fixed amount of a second one or a fixed dose ratio. No interaction is then often defined by a parallel shift of these curves. We have performed a systematic study for various types of dose-response relations both for the...
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To the Editor:—The critique by Eger et al. on the article by Eckenhoff and Johansson concerns combining the dose–response curves of several ion channels to make them steeper. The slopes of the in vivo studies are steep, whereas those of the in vitro studies are gradual. Both groups anticipate that when several binding sites among ion channels are combined, the dose–response curves may become st...
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The U.S. Environmental Protection Agency has developed a categorical logistic regression approach for regressing ordered response categories on one or more factors due to toxicant exposures. This approach can also be used in analyzing chemical warfare agent toxicity. Towards this end, three previous mammalian studies (involving acute inhalation exposures to G-type nerve agents) were reviewed an...
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ژورنال
عنوان ژورنال: Nonlinearity in Biology, Toxicology, Medicine
سال: 2004
ISSN: 1540-1421
DOI: 10.1080/15401420490426954