Dose Equivalents for Second-Generation Antipsychotics: The Minimum Effective Dose Method
نویسندگان
چکیده
منابع مشابه
Dose equivalents for second-generation antipsychotics: the minimum effective dose method.
BACKGROUND Clinicians need to know the right antipsychotic dose for optimized treatment, and the concept of dose equivalence is important for many clinical and scientific purposes. METHODS We refined a method presented in 2003, which was based on the minimum effective doses found in fixed-dose studies. We operationalized the selection process, updated the original findings, and expanded them ...
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BACKGROUND The concept of dose equivalence is important for many purposes. The classical approach published by Davis in 1974 subsequently dominated textbooks for several decades. It was based on the assumption that the mean doses found in flexible-dose trials reflect the average optimum dose which can be used for the calculation of dose equivalence. We are the first to apply the method to secon...
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We consider identifying the minimum effective dose (MED) in a dose-response study, where the MED is defined to be the lowest dose level producing an effect over that of the zero-dose control. Proposed herein is a nonparametric procedure based on the Mann-Whitney statistic incorporated with the step-down closed testing scheme. A numerical example demonstrates the feasibility of the proposed nonp...
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ژورنال
عنوان ژورنال: Schizophrenia Bulletin
سال: 2014
ISSN: 0586-7614,1745-1701
DOI: 10.1093/schbul/sbu001