Dosage compensation in human pre‐implantation embryos: X‐chromosome inactivation or dampening?
نویسندگان
چکیده
منابع مشابه
X chromosome inactivation is initiated in human preimplantation embryos.
X chromosome inactivation (XCI) is the mammalian mechanism that compensates for the difference in gene dosage between XX females and XY males. Genetic and epigenetic regulatory mechanisms induce transcriptional silencing of one X chromosome in female cells. In mouse embryos, XCI is initiated at the preimplantation stage following early whole-genome activation. It is widely thought that human em...
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X-chromosome inactivation (XCI) is an epigenetic mechanism that occurs in the eutherian embryo development to equalize the dosage of X-linked genes between males and females. This event is regulated by various factors, and the genes located in the X-chromosome inactivation center (XIC), which is known to be an evolutionary conserved region, are associated with XCI; however, a number of studies ...
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ژورنال
عنوان ژورنال: EMBO reports
سال: 2018
ISSN: 1469-221X,1469-3178
DOI: 10.15252/embr.201846294