Dosage Compensation and Gene Expression of the X Chromosome in Sheep
نویسندگان
چکیده
منابع مشابه
X-Chromosome dosage compensation.
In mammals, flies, and worms, sex is determined by distinctive regulatory mechanisms that cause males (XO or XY) and females (XX) to differ in their dose of X chromosomes. In each species, an essential X chromosome-wide process called dosage compensation ensures that somatic cells of either sex express equal levels of X-linked gene products. The strategies used to achieve dosage compensation ar...
متن کاملX-Chromosome Dosage Compensation
The X and Y chromosomes of placental and marsupial mammals originated from a pair of autosomes. Ohno hypothesised nearly 50 years ago that the expression levels of X-linked genes should be doubled to compensate for the degeneration of their Y-linked homologues during sex chromosome evolution. The advent of microarray and RNA (ribonucleic acid) sequencing technologies in the past decade prompted...
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a colon length of 15,000 crypts. The mean width of the observed adenomas was seven crypts (although this figure is an overestimate of x, because it was observed after any collisions had occurred, which presumably had the effect of increasing x). We analyzed the model assuming different values of n and determining whether these values can account for two observations: (i) the final figure of 300...
متن کاملGlobal analysis of X-chromosome dosage compensation
BACKGROUND Drosophila melanogaster females have two X chromosomes and two autosome sets (XX;AA), while males have a single X chromosome and two autosome sets (X;AA). Drosophila male somatic cells compensate for a single copy of the X chromosome by deploying male-specific-lethal (MSL) complexes that increase transcription from the X chromosome. Male germ cells lack MSL complexes, indicating that...
متن کاملMechanisms of X Chromosome Dosage Compensation
In many animals, males have one X and females have two X chromosomes. The difference in X chromosome dosage between the two sexes is compensated by mechanisms that regulate X chromosome transcription. Recent advances in genomic techniques have provided new insights into the molecular mechanisms of X chromosome dosage compensation. In this review, I summarize our current understanding of dosage ...
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ژورنال
عنوان ژورنال: G3 Genes|Genomes|Genetics
سال: 2019
ISSN: 2160-1836
DOI: 10.1534/g3.118.200815