DoReMi: context-based prioritization of linear motif matches
نویسندگان
چکیده
منابع مشابه
DoReMi: context-based prioritization of linear motif matches
Many protein domains bind to short peptide sequences, called linear motifs. Data on their sequence specificities is sparse, which is why biologists usually resort to basic pattern searches to identify new putative binding sites for experimental follow-up. Most motifs have poor specificity and prioritization of the matches is thus crucial when scanning a full proteome with a pattern. Here we pre...
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چکیده ندارد.
15 صفحه اولMasking residues using context-specific evolutionary conservation significantly improves short linear motif discovery
MOTIVATION Short linear motifs (SLiMs) are important mediators of protein-protein interactions. Their short and degenerate nature presents a challenge for computational discovery. We sought to improve SLiM discovery by incorporating evolutionary information, since SLiMs are more conserved than surrounding residues. RESULTS We have developed a new method that assesses the evolutionary signal o...
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Article history: Received 16 May 2013 Accepted 13 June 2014 Available online xxxx
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ژورنال
عنوان ژورنال: PeerJ
سال: 2014
ISSN: 2167-8359
DOI: 10.7717/peerj.315