Dopamine for renal protection

Renal dopamine system in chronic renal insufficiency

In the periphery, physiological dopamine increases renal blood flow, decreases renal resistance and acts on the kidney tubule to enhance natriuresis and diuresis. Dopamine receptors can be divided into D1-like (D1 and D5) receptors that stimulate adenylyl cyclase and D2-like (D2, D3 and D4) receptors that inhibit adenylyl cyclase. Both the D1-like and D2-like receptors are expressed in the kidn...

Perioperative Renal Protection during Cardiac Surgery: A Choice between Dopamine and Dexmedetomidine

Calcium antagonists and renal hemodynamics: implications for renal protection.

Recently, attention has focussed on the effects of calcium antagonists on renal function. When administered in vitro to the isolated perfused kidney, calcium antagonists exhibit consistent actions permitting characterization of their renal hemodynamic effects. Calcium antagonists do not affect the vascular tone of the vasodilated isolated perfused kidney, but they do dramatically reverse the re...

Perioperative renal protection

Acute renal failure (ARF) occurring around the time of surgery is a serious complication associated with considerable morbidity and mortality. Appropriate perioperative strategies are required to protect renal function to optimize patient outcome. Perioperative ARF accounts for 20–25% of cases of hospital-acquired renal failure. The incidence varies between 1 and 25% depending on the type of su...

N-Octanoyl Dopamine, a Non-Hemodyanic Dopamine Derivative, for Cell Protection during Hypothermic Organ Preservation

BACKGROUND Although donor dopamine treatment reduces the requirement for post transplantation dialysis in renal transplant recipients, implementation of dopamine in donor management is hampered by its hemodynamic side-effects. Therefore novel dopamine derivatives lacking any hemodynamic actions and yet are more efficacious in protecting tissue from cold preservation injury are warranted. We hyp...