Dopamine D4 receptor counteracts dopamine D2 receptor effect through different PKC isoenzymes
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چکیده
منابع مشابه
The Dopamine D4 Receptor
The observation that receptors which mediate their signals through heterotrimeric guanosine triphosphate (GTP)-binding proteins (Gproteins) share a considerable amount of sequence similarity has resulted in the rapid molecular characterization of this receptor superfamily. Moreover, it became clear that several receptor families consisted of more receptor subtypes than originally anticipated fr...
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The relationship of various dimensions of temperament, measured by the Tridimensional Personality Questionnaire (TPQ), to polymorphisms of the D2 dopamine receptor (DRD2) and D4 dopamine receptor (DRD4) genes was determined in 119 healthy Caucasian boys who had not yet begun to consume alcohol and other drugs of abuse. Total Novelty Seeking score of the TPQ was significantly higher in boys havi...
متن کاملDopamine receptor D2
Dopamine receptor D2, also known asD2R, is a protein that, in humans, is encoded by the DRD2 gene.The dopamine D2 receptor was discovered in 1975 by Philip Seeman who had named it as the antipsychotic/dopamine receptor [1] The dopamine D2 receptor is the main receptor for all antipsychotic drugs. Any drug that does not interfere with dopamine action at the D2 receptor does not have an antipsych...
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Chang H-W, Wu V-C, Huang C-Y, Huang H-Y, Chen Y-M, Chu T-S, Wu K-D, Hsieh B-S. D4 dopamine receptor enhances angiotensin II-stimulated aldosterone secretion through PKC-ε and calcium signaling. Am J Physiol Endocrinol Metab 294: E622–E629, 2008. First published January 2, 2008; doi:10.1152/ajpendo.00657.2007.—Aldosterone secretion is subjected to dopaminergic regulation. Our previous study show...
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We have examined the binding of two radioligands ([H]spiperone and [H]raclopride) to D2 dopamine receptors expressed in Chinese hamster ovary cells. In saturation binding experiments in the presence of sodium ions, both radioligands labeled a similar number of sites, whereas in the absence of sodium ions [H]raclopride labeled about half the number of sites labeled by [H]spiperone. In competitio...
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ژورنال
عنوان ژورنال: American Journal of Hypertension
سال: 2005
ISSN: 0895-7061
DOI: 10.1016/j.amjhyper.2005.03.626