Don’t Worry, We Have a New Weapon Against Cancer!

Curcumin: New Weapon against Cancer

All the evidences point out to the fact that the incidence, mortality and number of persons living with cancer are on the rise and, thus, this will impose a significant burden on health care resources. The considerable number of deaths from cancer necessitates the need to developing novel alternative cures that are efficient, safe, cheap and easy to use. In the search for new therapies for tumo...

Mir-34: A New Weapon Against Cancer?

The microRNA(miRNA)-34a is a key regulator of tumor suppression. It controls the expression of a plethora of target proteins involved in cell cycle, differentiation and apoptosis, and antagonizes processes that are necessary for basic cancer cell viability as well as cancer stemness, metastasis, and chemoresistance. In this review, we focus on the molecular mechanisms of miR-34a-mediated tumor ...

Mass Radiography: A new Weapon against Tuberculosis.

A new weapon against an old target

High expression of folate receptors is characteristic for the effector cell population of synovial macrophages in synovial inflammation. A new drug conjugate, EC0746, targets the folate inhibitor aminopterin to folate receptors. In vitro studies show that this conjugate acts antiproliferatively and inhibits cytokine production by macrophage cell lines. Moreover, it shows strong anti-arthritic e...

Why we (usually) don’t have to worry about multiple comparisons

Applied researchers often find themselves making statistical inferences in settings that would seem to require multiple comparisons adjustments. We challenge the Type I error paradigm that underlies these corrections. Moreover we posit that the problem of multiple comparisons can disappear entirely when viewed from a hierarchical Bayesian perspective. We propose building multilevel models in th...