Donor-Specific HLA Antibody IgG Subclasses Are Associated with Phenotypes of Antibody-Mediated Rejection in Sensitized Renal Allograft Recipients
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چکیده
منابع مشابه
Donor-Specific HLA Antibody IgG Subclasses Are Associated with Phenotypes of Antibody-Mediated Rejection in Sensitized Renal Allograft Recipients.
Donor-specific anti–histocompatibility leukocyte antigen antibodies (DSAs) have a strong and frequently considered universally deleterious effect on allografts. Preformed or de novo DSAs activate complement, induce endothelial cell proliferation, and mediate antibody-dependent cellular cytotoxicity (ADCC), resulting in progressive declines in allograft function and loss.1–3More than 5000 renal ...
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Detection of donor-specific human leukocyte antigen (HLA) antibodies is an important part of diagnosis of antibody-mediated rejection (AMR) in the renal transplant population. Donor-specific antibodies (DSA) against HLA-C, a Class 1 major histocompatibility gene product, are not considered to be of major importance in renal transplant rejection. Typing for HLA-C is not a routine part of pre- an...
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ژورنال
عنوان ژورنال: Journal of the American Society of Nephrology
سال: 2015
ISSN: 1046-6673,1533-3450
DOI: 10.1681/asn.2015060608