Does Metformin combined with Clomiphene Citrate improve fertility related outcomes in Clomiphene resistant women with PCOS: A systematic review

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Efficacy of combined metformin–clomiphene citrate in comparison with clomiphene citrate alone in infertile women with polycystic ovarian syndrome (PCOS)

BACKGROUND Polycystic ovary syndrome (PCOS) is the most common endocrinopathy in women and is associated with the reproductive and metabolic disorders. OBJECTIVES To compare the ovulation and conception rates after the treatment with Clomiphene Citrate (CC) alone and in combination with metformin in infertile patients presented with polycystic ovarian syndrome (PCOS). MATERIAL & METHODS Thi...

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Metformin-letrozole in comparison with Metformin-clomiphene citrate in clomiphene-resistance PCOS patients undergoing IUI

BACKGROUND Polycystic ovary syndrome (PCOS) is associated with approximately 75% of women who suffer from infertility due to anovulation. Additionally, around 20- 25% of anovulatory women with PCOS do not respond at all to clomiphene citrate and are considered to be "clomiphene- resistant". Aromatase inhibitors have been suggested as an alternative treatment to clomiphene as the discrepancy bet...

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P-158: Metformin versus Chromium Picolinate in Clomiphene Citrate-Resistant Patients with Polycystic Ovary

Background: To compare the chromium picolinate with metformin in Clomiphene citrate resistant PCOS patients. Materials and Methods: This was a randomized clinical trial being performed at university affiliated clinics including 92 women with Clomiphene citrate-resistant PCOS who were randomly assigned to receive chromium picolinate (200 μg daily) or metformin (1500 mg daily) for 3 months. Anthr...

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metformin-letrozole in comparison with metformin-clomiphene citrate in clomiphene-resistance pcos patients undergoing iui

background: polycystic ovary syndrome (pcos) is associated with approximately 75% of women who suffer from infertility due to anovulation. additionally, around 20– 25% of anovulatory women with pcos do not respond at all to clomiphene citrate and are considered to be “clomiphene– resistant”. aromatase inhibitors have been suggested as an alternative treatment to clomiphene as the discrepancy be...

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Clomiphene Resistant PCOS: Treatment Options

Clomiphene Citrate (Clomid, Serophene) was introduced into clinical medicine for the treatment of anovulation in the 1960’s. Its introduction represented a major breakthrough in the medical management for ovulation induction. Prior to Clomiphene, patients with PCOS who were anovulatory had few options besides weight loss and surgical wedge resection of the ovaries. While wedge resection was suc...

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ژورنال

عنوان ژورنال: Middle East Fertility Society Journal

سال: 2014

ISSN: 1110-5690

DOI: 10.1016/j.mefs.2014.04.002