Docking, synthesis and biological evaluation of pyridine ring containing Diaryl urea derivatives as anticancer agents

A novel series of pyridine ring containing diaryl urea derivatives (R1-R9) were synthesized in four chemical steps using pyridine-2-carboxylic acid as starting material. The compounds design by Autodock vina the crystal structure Kinase domain Human B-raf (PDB ID: 4DBN) to get insights into structural requirements for anticancer activity. In vitro activity against cell line (MCF-7) showed that R3, R6 and R9 found be most potent (Docking score: > -12, IC50 = 17.39 µM) among molecules.