Docking Simulation Analysis of Natural Ingredients as Anti Virus SARS-Cov-2 on Helicase Inhibitors

Aims: To find active compounds from natural ingredients that have the potential to be antivirals of SARS-CoV-2.
 Study Design: Simulation research.
 Place and Duration Study: Physics Laboratory, Department Education, Universitas Kristen Indonesia, between December 2021 August 2022.
 Methodology: The method used is a computational simulation commonly known as docking or molecular docking. There are several steps taken, namely ligand receptor preparation, analysis results.
 Results: results obtained were 22 material selected helicase inhibitors, 14 found met requirements according Lipinski's five rules, Emodin, Luteolin, Curcumin, Kaemferol, Quercetin, Myricetin, Scutellarein, 10-Gingerol, Shogaol, Mangostin, Piseatanol, Diallyl disulfide, Cyperotundone Eugenol. Of simulated with receptors, it turned out stable inhibitors. However, among ligands, myricetin most smallest Gibbs free energy value, which -8.7 kcal/mol.
 Conclusion: An ingredient compound has been an antivirus sars-COV-2 in Helicase receptor, Myricetin clove plants (Syzygium aromaticum). These can basis for drug development SARS-COV-2 future.