Do sulfonylureas still have a role in type 2 diabetes?
نویسندگان
چکیده
منابع مشابه
Pioglitazone and sulfonylureas: effectively treating type 2 diabetes
Type 2 diabetes is characterised by a gradual decline in glycaemic control and progression from oral glucose-lowering monotherapy to combination therapy and exogenous insulin therapy. Functional decline of the insulin-secreting beta-cells is largely responsible for the deterioration in glycaemic control. Preservation of beta-cell functionality, in addition to maintaining glycaemic control and r...
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متن کاملIs There Enhanced Risk of Cerebral Ischemic Stroke by Sulfonylureas in Type 2 Diabetes?
Hyperglycemia enhances stroke injury in humans and experimental animals, and type 2 diabetes mellitus (T2DM) is a known risk factor for stroke. Sulfonylurea (SU) drugs have been used for over six decades for management of T2DM; they exhibit their principal antidiabetes property by inhibiting KATP channels and promoting an increase in insulin secretion by pancreatic b-cells (1,2) (Fig. 1A). The ...
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BACKGROUND AND PURPOSE The sulfonylurea receptor 1-regulated NC(Ca-ATP) channel is upregulated in rodent models of stroke with block of the channel by the sulfonylurea, glibenclamide (glyburide), significantly reducing mortality, cerebral edema, and infarct volume. We hypothesized that patients with type 2 diabetes mellitus taking sulfonylurea agents both at the time of stroke and during hospit...
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ژورنال
عنوان ژورنال: Prescriber
سال: 2011
ISSN: 0959-6682
DOI: 10.1002/psb.759