Do NIHR health technology assessment randomised clinical trials perform as well as expected?
نویسندگان
چکیده
منابع مشابه
Do NIHR health technology assessment randomised clinical trials perform as well as expected?
Results 125 clinical trials published in the HTA Journal Series met the inclusion. Five trials were reported to have been abandoned and were excluded from analyses. 72% of clinical trials achieved 50% or better of their original recruitment target. 90% of clinical trials recruited their targeted number of centres with 50% recruiting more than the initial number they expected. One third of trial...
متن کاملAdverse Event Reporting in Clinical Trials: Time to Include Duration as Well as Severity
Assessing the efficacy of therapy involves a complex interplay between the risks and benefits within particular patient populations. The concept of patient benefit has been well established. Direct patient benefits are typically assessed with regard to patients living longer, living better, or both. Assessing risks of therapy can be more difficult. To properly assess risks, one must have a clea...
متن کاملRole of NIHR HTA clinical trials on subsequent systematic reviews
Results The preliminary findings from the Cochrane Library found 28 trials out of the eligible 121 trials (excluding four pilot and feasibility studies) were found in a subsequent Cochrane systematic review. The weight of the included HTA trials varied widely (from 100% to 9%). In eight reviews, the trial had a weight of 100% indicating how the trial provided the only evidence for that particul...
متن کاملLaboratory Medicine as a Profession and Clinical Science – How to Perform Both of them well?
Laboratory Medicine as a profession and clinical science – how to perform both of them well? Laboratory diagnostics is the medical discipline devoted to obtain, explore and employ knowledge about using various techniques for the analysis of body fluids composition and properties of cells and tissues, and interpretation of the results in relation to health and disease. It should be stressed that...
متن کاملA review of recruitment of children to randomised clinical trials in the NIHR clinical research network portfolio
Methods Randomised clinical trials of any health care intervention, conducted between 2006 and 2012 and closed to recruitment, were identified. Recruitment performance was assessed by comparing achieved to planned recruitment. Putative factors affecting recruitment will be tested for association with successful recruitment, defined initially as recruitment to 100% of target in the planned time ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Trials
سال: 2013
ISSN: 1745-6215
DOI: 10.1186/1745-6215-14-s1-p92