Do ΔF508 heterozygotes have a selective advantage?
نویسندگان
چکیده
منابع مشابه
Do ΔF508 Heterozygotes Have A Selective Advantage Against Influenza Virus?
The ΔF508 CFTR mutation, which is the commonest cause of cystic fibrosis (CF), has the highest frequency of any genetic mutation among Caucasians of central European origin. Persistence of a mutation suggests that heterozygosity for this mutation imparts some genetic advantage. We hypothesized that heterozygosity provides a selective survival advantage during influenza pneumonitis, as a result ...
متن کاملDo ∆F508 heterozygotes have a selective advantage?
In this paper the fitness of the ∆F508 heterozygote is assessed and the age of the ∆F508 mutation in the cystic fibrosis locus is estimated. Data from three microsatellite loci are applied. The analysis is performed conditional on the present-day frequency of the ∆F508 mutation and based on assumptions about the demographic history of the European population and the mutation rate in the three m...
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Private banks often blame state guarantees to distort competition by giving public banks the advantage of lower funding costs. In this paper I show that if borrowers perceive the public bank as supporting economic development, private banks may be able to separate firms by self selection, enter the market, and obtain profits in equilibrium despite their cost disadvantage. The public bank’s comp...
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ژورنال
عنوان ژورنال: Genetical Research
سال: 2001
ISSN: 0016-6723,1469-5073
DOI: 10.1017/s0016672301005195