Do cholinesterase inhibitors alter the course of dementia?
نویسندگان
چکیده
منابع مشابه
Cholinesterase inhibitors in the treatment of dementia.
Dementia associated with probable Alzheimer's disease (AD) is one of the most common types of dementia. Patients with AD often have cholinergic deficits in association with the disease. The cholinesterase inhibitors donepezil hydrochloride, galantamine hydrobromide, and rivastigmine tartrate are the current mainstays of symptomatic treatment for patients with AD. In clinical trials for all thre...
متن کاملUse of cholinesterase inhibitors in dementia
Alzheimer’s disease is the most common cause of dementia in older people, with about half a million people affected in the UK. Its effects are devastating and far-reaching for sufferers, their carers and society in general – the Audit Commission estimated the annual cost of dementia care for 1998–1999 at £6.1 billion (Audit Commission, 2000). There is no cure and it is terminal within 3 to 7 ye...
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Although psychoactive drugs are commonly used by AIDS patients, it is unclear whether commonly abused drugs, such as cocaine and ethanol, affect the course of HIV-associated dementia (HADC). Epidemiological studies have resulted in conflicting conclusions as to what role, if any, abused drugs play in HADC. In this review we discuss the clinical and pathological evidence that cocaine and ethanol...
متن کاملACP Journal Club. Review: cholinesterase inhibitors do not reduce progression to dementia from mild cognitive impairment.
Review scope Included studies compared ChEIs (donepezil, rivastigmine, galantamine, or tacrine) with placebo for ≥ 1 month in adults with mild cognitive impairment (as defined by each study but including subjective memory complaint and relatively preserved daily functioning). Primary outcomes were progression to dementia, which included Alzheimer disease (National Institute of Neurological and ...
متن کاملTreatment of dementia in parkinsonian syndromes with cholinesterase inhibitors.
In Parkinsonian syndromes behavioural symptoms and dementia can be even more debilitating than motor symptoms and are an important predictor for nursing home placement and mortality. Neuropathologically, dementia seems to be primarily related to cortical changes rather than to subcortical alterations. Concerning neurotransmitter systems, the cholinergic system has been proposed to play a key ro...
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ژورنال
عنوان ژورنال: Progress in Neurology and Psychiatry
سال: 2007
ISSN: 1367-7543,1931-227X
DOI: 10.1002/pnp.26