منابع مشابه
Let-7 Sensitizes KRAS Mutant Tumor Cells to Chemotherapy
KRAS is the most commonly mutated oncogene in human cancers and is associated with poor prognosis and drug resistance. Let-7 is a family of tumor suppressor microRNAs that are frequently suppressed in solid tumors, where KRAS mutations are highly prevalent. In this study, we investigated the potential use of let-7 as a chemosensitizer. We found that let-7b repletion selectively sensitized KRAS ...
متن کاملRole of Microrna Let-7 in Pancreatic Beta Cells
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متن کاملAn anti-let-7 sponge decoys and decays endogenous let-7 functions
The let-7 family contains 12 members, which share identical seed regions, suggesting that they may target the same mRNAs. It is essential to develop a means that can regulate the functions of all members. Using a DNA synthesis technique, we have generated an anti-let-7 sponge aiming to modulate the function of all members. We found that products of the anti-let-7 construct could bind and inacti...
متن کاملIdentification of let-7-regulated oncofetal genes.
MicroRNAs (miRNA) are small RNA molecules of approximately 20 to 22 nucleotides that reduce expression of proteins through mRNA degradation and/or translational silencing. Each known miRNA has a large number of predicted targets. Members of the let-7/miR-98 family of miRNAs are up-regulated at the end of embryonic development. Let-7 is often down-regulated early during cancer development, sugge...
متن کاملThe LIN28/let-7 Pathway in Cancer
Among all tumor suppressor microRNAs, reduced let-7 expression occurs most frequently in cancer and typically correlates with poor prognosis. Activation of either LIN28A or LIN28B, two highly related RNA binding proteins (RBPs) and proto-oncogenes, is responsible for the global post-transcriptional downregulation of the let-7 microRNA family observed in many cancers. Specifically, LIN28A binds ...
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ژورنال
عنوان ژورنال: Cell Stem Cell
سال: 2008
ISSN: 1934-5909
DOI: 10.1016/j.stem.2007.12.003