منابع مشابه
[DNA replication fidelity].
DNA replication fidelity plays fundamental role in faithful transmission of genetic material during cell division and during transfer of genetic material from parents to progeny. Replicative polymerases are the main guardian responsible for high replication fidelity of genomic DNA. DNA main replicative polymerases are also involved in many DNA repair processes. High fidelity of DNA replication ...
متن کامل7 Fidelity of DNA Replication
The six billion nucleotides of the diploid human genome are replicated in only a few hours while generating so few errors that the spontaneous mutation rate may be less than 1 mutation per genome per cell division (Loeb 1991). This incredible accuracy results from three major erroravoidance processes: the high selectivity of DNA polymerases, exonucleolytic proofreading, and postreplication mism...
متن کاملKunkel on DNA Replication Fidelity
Background: Caenorhabditis elegans is an important model for the study of DNA damage and repair related processes such as aging, neurodegeneration, and carcinogenesis. However, DNA repair is poorly characterized in this organism. We adapted a quantitative polymerase chain reaction assay to characterize repair of DNA damage induced by ultraviolet type C (UVC) radiation in C. elegans, and then te...
متن کاملOn the Fidelity of DNA Replication
Homogeneous DNA polymerase (“reverse transcriptase”) from avian myeloblastosis virus was assayed for exodeoxyribonuclease activity. The substrates were defined template. initiator complexes in which different radioactive nucleotides were present at the 3’-OH termini of the initiator. Even when the number of molecules of enzyme was equal to the number of initiator termini, there was no significa...
متن کاملOn the fidelity of DNA replication.
Homogeneous DNA polymerase (“reverse transcriptase”) from avian myeloblastosis virus was assayed for exodeoxyribonuclease activity. The substrates were defined template. initiator complexes in which different radioactive nucleotides were present at the 3’-OH termini of the initiator. Even when the number of molecules of enzyme was equal to the number of initiator termini, there was no significa...
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ژورنال
عنوان ژورنال: Seminars in Cancer Biology
سال: 2010
ISSN: 1044-579X
DOI: 10.1016/j.semcancer.2010.10.009