منابع مشابه
DNA-Repair Capacity in Down\'s Syndrome
Down's syndrome (DS) is the most common chromosomal abnormality in human. Subjects with DS are known to be peridisposed to develop leukemia. The molecular basis of the association between DS and leukemia is unknown. The unscheduled DNA synthesis (UDS) test measure the ability of DNA-repair in mammalian cells after excision of a stretch of DNA containing the region of damage induced by chemical ...
متن کاملThe Role of Long Non Coding RNAs in the Repair of DNA Double Strand Breaks
DNA double strand breaks (DSBs) are abrasions caused in both strands of the DNA duplex following exposure to both exogenous and endogenous conditions. Such abrasions have deleterious effect in cells leading to genome rearrangements and cell death. A number of repair systems including homologous recombination (HR) and non-homologous end-joining (NHEJ) have been evolved to minimize the fatal effe...
متن کاملZ-DNA: a prodrome for the 1990s.
Two duplexes could become unwound locally in homologous regions which, it might be argued, could then rewind to form regions of hybrid DNA. The difficulty with this scheme is that, without breaks, each right-hand turn of the hybrid helix generated in this way must be compensated by a left-hand turn. No one who has attempted to build a stable left-handed double helix with molecular models has su...
متن کاملRecombinational DNA repair: the ignored repair systems.
The recent finding of a role for the recA gene in DNA replication restart does not negate previous data showing the existence of recA-dependent recombinational DNA repair, which occurs when there are two DNA duplexes present, as in the case for recA-dependent excision repair, for postreplication repair (i.e., the repair of DNA daughter-strand gaps), and for the repair of DNA double-strand break...
متن کاملIRM in the 1990s
from the Database Directions Technologies for IRM 49 Workshop Editors 1 Alfonso F. Cardenas Elizabeth N. Fong, Alan H. Goldfine IRM in a Decentralized/Distributed Introduction 1 Environment 66 Robert M. Curtice Olin Bray SPECIAL ISSUE FROM THE FOURTH DATABASE DIRECTIONS WORKSHOP: INFORMATION RESOURCE MANAGEMENT—MAKING IT WORK Chairperson, Technical Committee on Database Engineering Prot. Gio Wi...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Cell
سال: 1999
ISSN: 0092-8674
DOI: 10.1016/s0092-8674(00)80634-0