منابع مشابه
DNA Repair in Drosophila
Both genetic and biochemical approaches have been used to study the molecular mechanisms by which damaged DNA is repaired in a number of species. The fundamental DNA repair pathways have been functionally conserved for the most part among prokaryotes, lower eukaryotes, and higher eukaryotes, and the proteins and protein families involved in these repair processes show high degrees of amino acid...
متن کاملDNA Repair in Drosophila : Insights from the Drosophila Genome Sequence
Both genetic and biochemical approaches have been used to study the molecular mechanisms by which damaged DNA is repaired in a number of species. The fundamental DNA repair pathways have been functionally conserved for the most part among prokaryotes, lower eukaryotes, and higher eukaryotes, and the proteins and protein families involved in these repair processes show high degrees of amino acid...
متن کاملDNA-Repair Capacity in Down\'s Syndrome
Down's syndrome (DS) is the most common chromosomal abnormality in human. Subjects with DS are known to be peridisposed to develop leukemia. The molecular basis of the association between DS and leukemia is unknown. The unscheduled DNA synthesis (UDS) test measure the ability of DNA-repair in mammalian cells after excision of a stretch of DNA containing the region of damage induced by chemical ...
متن کاملBiochemical activities and genetic functions of the Drosophila melanogaster Fancm DNA helicase in DNA repair
Repair of DNA damage is essential to the preservation of genomic stability. During repair of double-strand breaks, several helicases function to promote accurate repair and prevent the formation of crossovers through homologous recombination. Among these helicases is the Fanconi anemia group M (FANCM) protein. FANCM is important in the response to various types of DNA damage and has been sugges...
متن کاملUbiquitous overexpression of the DNA repair factor dPrp19 reduces DNA damage and extends Drosophila life span
Mechanisms that ensure and maintain the stability of genetic information are fundamentally important for organismal function and can have a large impact on disease, aging, and life span. While a multi-layered cellular apparatus exists to detect and respond to DNA damage, various insults from environmental and endogenous sources continuously affect DNA integrity. Over time this can lead to the a...
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ژورنال
عنوان ژورنال: Journal of Cell Biology
سال: 2000
ISSN: 0021-9525,1540-8140
DOI: 10.1083/jcb.150.2.f31