DNA Profiling Using Solid-State Nanopores: Detection of DNA-Binding Molecules
نویسندگان
چکیده
منابع مشابه
DNA profiling using solid-state nanopores: detection of DNA-binding molecules.
We present a novel single-molecule method for rapidly evaluating small-molecule binding to individual DNA molecules using nanopores fabricated in ultrathin silicon membranes. A measurable shift in the residual ion current through a approximately 3.5 nm pore results from threading of a dye-intercalated DNA molecule, as compared to the typical residual current of native DNA. The average level of ...
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ژورنال
عنوان ژورنال: Nano Letters
سال: 2009
ISSN: 1530-6984,1530-6992
DOI: 10.1021/nl901691v