DNA methylation mutants inPhyscomitrella patenselucidate individual roles of CG and non-CG methylation in genome regulation

DNA Methylation Profiling Identifies CG Methylation Clusters in Arabidopsis Genes

Cytosine DNA methylation in vertebrates is widespread, but methylation in plants is found almost exclusively at transposable elements and repetitive DNA. Within regions of methylation, methylcytosines are typically found in CG, CNG, and asymmetric contexts. CG sites are maintained by a plant homolog of mammalian Dnmt1 acting on hemi-methylated DNA after replication. Methylation of CNG and asymm...

RNAi, DRD1, and Histone Methylation Actively Target Developmentally Important Non-CG DNA Methylation in Arabidopsis

Cytosine DNA methylation protects eukaryotic genomes by silencing transposons and harmful DNAs, but also regulates gene expression during normal development. Loss of CG methylation in the Arabidopsis thaliana met1 and ddm1 mutants causes varied and stochastic developmental defects that are often inherited independently of the original met1 or ddm1 mutation. Loss of non-CG methylation in plants ...

Role of CG and Non-CG Methylation in Immobilization of Transposons in Arabidopsis

Methylation of cytosine residues in eukaryotic genomes is often associated with repeated sequences including transposons and their derivatives. Methylation has been implicated in control of two potential deleterious effects of these repeats: (1) uncontrolled transcription, which often disturbs proper expression of nearby host genes, and (2) changes in genome structure by transposition and ectop...

Non-CG methylation patterns shape the epigenetic landscape in Arabidopsis

DNA methylation has roles in different biological processes such as gene regulation and imprinting. In Arabidopsis, DNA is methylated in three cytosine contexts: CG, CHG and CHH (where H denotes A, T or C)1. In mammals, DNA is primarily methylated in CG contexts; however, studies have uncovered the presence of non-CG methylation in certain cell types such as embryonic stem cells and brain cells...

Title: Role of CG Context and Content in Evolutionary Signatures of Brain DNA Methylation Running Head: CG Context and Content in Brain DNA Methylation