DNA Methylation--A Regulatory Signal in Eukaryotic Gene Expression

DNA methylation--a regulatory signal in eukaryotic gene expression.

Key Regulatory Gene Expression in Erythroleukemia Differentiation

The characteristics of cellular and molecular mechanisms associated with cell proliferation and differentiation is important to understand malignancy. In this report we characterise a leukemic model, D5A1, to study the action of differentiation agent, cellular events and gene expression of the selected transcription factors. Cells induced with 4 mM hexamethylene bisacetamide (HMBA) caused signs...

DNA methylation versus gene expression.

Vertebrate DNA is methylated at a high proportion of cytosine residues in the sequence CpG, and it has been suggested that the distribution of methylated and non-methylated CpGs in a given cell type influences the pattern of gene expression in those cells. Since a DNA methylation pattern is normally transmitted faithfully to daughter cells via cell division, this idea suggests an origin for sta...

DNA methylation as a regulatory mechanism for gene expression in mammals.

Epigenetics refers to the study of heritable changes in gene expression that occur without a change in DNA sequence. In the last decade, it has been shown that epigenetic mechanisms provide an "extra" layer of transcriptional control that regulates genes expression. Three distinct mechanisms appear intricately related in initiating and sustaining epigenetic modifications: RNA-associated silenci...

Conservation and divergence in eukaryotic DNA methylation.

C ytosine methylation is a common DNA modification found in most eukaryotic organisms including plants, animals, and fungi (1, 2). The addition of a methyl group to cytosine nucleotides in DNA does not change the primary DNA sequence, but the covalent modification of DNA by methylation can impact gene expression and activity in a heritable fashion. This type of epigenetic regulation through DNA...