DNA-mediated immunization of mice with plasmid encoding HBs antigen
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چکیده
منابع مشابه
DNA-mediated immunization of mice with plasmid encoding HBs antigen.
In order to develop an experimental DNA vaccine for the prevention and treatment of hepatitis B virus infection, hepatitis B virus surface antigen (HBsAg) DNA was subcloned into an E. coli-eukaryotic cell shuttle vector and was expressed in the Baculovirus expression system. Intramuscular, intradermal, and intraperitoneal injections of 30 microg of the plasmid DNA expressing HBsAg induced humor...
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Background: DNA immunization with plasmid DNA encoding bacterial, viral, parasitic and tumor antigens has been reported to trigger protective immunity. Objective: To evaluate the use of a DNA immunization strategy for protection against anthrax, a plasmid was constructed. Methods: The partialsequence of protective antigen of Bacillus anthracis, amino acids 175-764, as a potent immunogenic targe...
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A scientific review of bovine tuberculosis in Great Britain has concluded that the development of a cattle vaccine holds the best prospect for long-term disease control. Recent reports of successful DNA vaccination against Mycobacterium tuberculosis in small animal models have raised the possibility of using a similar strategy to produce vaccines against Mycobacterium bovis infection in cattle....
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The development of protective immunity against many intracellular bacterial pathogens commonly requires sublethal infection with viable forms of the bacteria. Such infection results in the in vivo activation of specific cell-mediated immune responses, and both CD4+ and CD8+ T lymphocytes may function in the induction of this protective immunity. In rodent models of experimental infection with L...
متن کاملevaluation of immunization of balb/c mice by plasmid encoding complete rop2 gene of toxoplasma gondii
objective: toxoplasma gondii is an obligate intracellular protozoan that causes toxoplasmosis in human and animal. in recent years, significant progress has been made in the identification of vaccine candidates which can induce protective responses. in this study we used complete rhoptry protein 2 gene of toxoplasma gondii as a single dna vaccine and evaluated its immune responses in comparison...
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ژورنال
عنوان ژورنال: Journal of Korean Medical Science
سال: 1999
ISSN: 1011-8934,1598-6357
DOI: 10.3346/jkms.1999.14.2.187