DNA Logic Gate Based on Metallo-Toehold Strand Displacement
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چکیده
منابع مشابه
DNA Logic Gate Based on Metallo-Toehold Strand Displacement
DNA is increasingly being used as an ideal material for the construction of nanoscale structures, circuits, and machines. Toehold-mediated DNA strand displacement reactions play a very important role in these enzyme-free constructions. In this study, the concept of metallo-toehold was utilized to further develop a mechanism for strand displacement driven by Ag+ ions, in which the intercalation ...
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In biomolecular programming, the properties of biomolecules such as proteins and nucleic acids are harnessed for computational purposes. The field has gained considerable attention due to the possibility of exploiting the massive parallelism that is inherent in natural systems to solve computational problems. DNA has already been used to build complex molecular circuits, where the basic buildin...
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We study the thermodynamics and kinetics of an RNA toehold-mediated strand displacement reaction with a recently developed coarse-grained model of RNA. Strand displacement, during which a single strand displaces a different strand previously bound to a complementary substrate strand, is an essential mechanism in active nucleic acid nanotechnology and has also been hypothesized to occur in vivo....
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DNA is increasingly being used as the engineering material of choice for the construction of nanoscale circuits, structures, and motors. Many of these enzyme-free constructions function by DNA strand displacement reactions. The kinetics of strand displacement can be modulated by toeholds, short single-stranded segments of DNA that colocalize reactant DNA molecules. Recently, the toehold exchang...
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Niranjan Srinivas,∗,† Thomas E. Ouldridge,∗,‡ Petr Šulc,‡ Joseph M. Schaeffer,† Bernard Yurke,¶ Ard A. Louis,‡ Jonathan P. K. Doye§ and Erik Winfree† ∗Both these authors contributed equally to this work. Email: [email protected], [email protected] †California Institute of Technology, 1200 E California Blvd., Pasadena, CA 91125 ‡Rudolph Peierls Centre for Theoretical Physics, 1 Ke...
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ژورنال
عنوان ژورنال: PLoS ONE
سال: 2014
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0111650