DNA damage by low concentration of hydrogen peroxide.
نویسندگان
چکیده
منابع مشابه
Evaluating the effects of galbanic acid on hydrogen peroxide-induced oxidative DNA damage in human lymphocytes
Objective: Ferula szowitsiana has been widely used for medicinal purposes around the world. The anti-oxidant effect of F.szowitsiana had been proved. The current study aims to determine the protective effects of galbanic acid, a sesquiterpene coumarin from F. szowitsiana, against hydrogen peroxide (H2O2) - induced oxidative DNA damage in human lymphocytes. Materials and Methods: Human lymphocyt...
متن کاملevaluating the effects of galbanic acid on hydrogen peroxide-induced oxidative dna damage in human lymphocytes
objective: ferula szowitsiana has been widely used for medicinal purposes around the world. the anti-oxidant effect of f.szowitsiana had been proved. the current study aims to determine the protective effects of galbanic acid, a sesquiterpene coumarin from f. szowitsiana, against hydrogen peroxide (h2o2) - induced oxidative dna damage in human lymphocytes. materials and methods: human lymphocyt...
متن کاملDetermination of absolute hydrogen peroxide concentration by spectrophotometric method
There is considerable current interest in oxidative stress applicable to humans. One important reactive oxygen species generated in the body is H2O2. It was reported that substantial amount of H2O2 was excreted in urine, even in neonates. Therefore, it was hypothesized earlier that measurement of H2O2, especially in urine, could be a valuable biomarker for the generation of H2O2 and the degree ...
متن کاملCell killing and DNA damage by hydrogen peroxide are mediated by intracellular iron.
Phenanthroline, a strong iron chelator, prevents both the formation of DNA single-strand breaks and the killing of mouse cells produced by H2O2. These results, taken together with our previous findings, indicate that the DNA damage is produced by hydroxyl radicals formed when H2O2 reacts with chromatin-bound Fe2+ and that this damage is responsible for the killing effect.
متن کاملFormation, prevention, and repair of DNA damage by iron/hydrogen peroxide.
Although oxygen is a powerful oxidant, the triplet ground state of dioxygen constitutes a kinetic barrier for oxidation of biological molecules, which are mostly singlet state (1). However, the unpaired orbitals of dioxygen can sequentially accommodate single electrons to yield O2 ., H2O2, the very reactive zOH, and water (Fig. 1, Reaction 1). The oxidative potential of atmospheric oxygen is ma...
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ژورنال
عنوان ژورنال: Agricultural and Biological Chemistry
سال: 1989
ISSN: 0002-1369,1881-1280
DOI: 10.1271/bbb1961.53.835