DNA Cross-Linking by Dehydromonocrotaline Lacks Apparent Base Sequence Preference
نویسندگان
چکیده
منابع مشابه
DNA cross-linking by dehydromonocrotaline lacks apparent base sequence preference.
Pyrrolizidine alkaloids (PAs) are ubiquitous plant toxins, many of which, upon oxidation by hepatic mixed-function oxidases, become reactive bifunctional pyrrolic electrophiles that form DNA-DNA and DNA-protein cross-links. The anti-mitotic, toxic, and carcinogenic action of PAs is thought to be caused, at least in part, by these cross-links. We wished to determine whether the activated PA pyrr...
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ژورنال
عنوان ژورنال: Toxicological Sciences
سال: 2004
ISSN: 1096-0929
DOI: 10.1093/toxsci/kfh262