DNA-Binding Activities of Hop1 Protein, a Synaptonemal Complex Component from Saccharomyces cerevisiae

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DNA-binding activities of Hop1 protein, a synaptonemal complex component from Saccharomyces cerevisiae.

The meiosis-specific HOP1 gene is important both for crossing over between homologs and for production of viable spores. hop1 diploids fail to assemble synaptonemal complex (SC), which normally provides the framework for meiotic synapsis. Immunochemical methods have shown that the 70-kDa HOP1 product is a component of the SC. To assess its molecular function, we have purified Hop1 protein to ho...

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ژورنال

عنوان ژورنال: Molecular and Cellular Biology

سال: 1998

ISSN: 0270-7306,1098-5549

DOI: 10.1128/mcb.18.3.1424