DMT1: Which metals does it transport?

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چکیده

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DMT1: which metals does it transport?

DMT1-Divalent Metal (Ion) Transporter 1 or SLC11A2/DCT1/Nramp2 - transports Fe2+ into the duodenum and out of the endosome during the transferrin cycle. DMTI also is important in non-transferrin bound iron uptake. It plays similar roles in Mn2+ trafficking. Voltage clamping showed that six other metals evoked currents, but it is unclear if these metals are substrates for DMT1. This report summa...

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ژورنال

عنوان ژورنال: Biological Research

سال: 2006

ISSN: 0716-9760

DOI: 10.4067/s0716-97602006000100009