DMSO-Perturbing Assay for Identifying Promiscuous Enzyme Inhibitors
نویسندگان
چکیده
منابع مشابه
Promiscuous Aggregate-Based Inhibitors Promote Enzyme Unfolding
One of the leading sources of false positives in early drug discovery is the formation of organic small molecule aggregates, which inhibit enzymes nonspecifically at micromolar concentrations in aqueous solution. The molecular basis for this widespread problem remains hazy. To investigate the mechanism of inhibition at a molecular level, we determined changes in solvent accessibility that occur...
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ژورنال
عنوان ژورنال: ACS Medicinal Chemistry Letters
سال: 2019
ISSN: 1948-5875,1948-5875
DOI: 10.1021/acsmedchemlett.9b00093